Identifying the Issue
Objective of the Research
Who should read this?
Research community working in the Antiplasmodial drug development, medicinal chemists, and pharmaceutical industry
Solution
Development of nontoxic small molecules with high therapeutic effect and selectivity.
Key Features and Benefits
Impact
Team
Siva Kumar Rokkam,# Mamta Yadav,# Mayank Joshi, Angshuman Roy Choudhury, Dinkar Sahal* and Nageswara Rao Golakoti*.
* Corresponding authors, #Equal contributions.
Title of paper: Synthesis, in vitro anti-plasmodial potency, in-silico-cum-SPR binding with inhibition of Pf Pyridoxal synthase and rapid parasiticidal action by 3,5-bis {(E) arylidene}-N-methyl-4-piperidones
Read Paper Here: https://doi.org/10.1039/D1NJ04604G
Fig. Antiplasmodial and antimalarial properties of DANMPs, a) Synthesis and characterization; b) interaction of the lead molecule with pyridoxal phosphate synthase; c) inhibition of parasitemia and cell cycle progression of PfMRA-1240 trophozoites in the presence of the lead molecule; d) best lead compound and its antiplasmodial potency.
Identifying the Issue
Objective of the Research
Who should read this?
Research community working in anti-inflammatory drug development, medicinal chemists, and the pharmaceutical industry
Solution
Development of nontoxic small molecules with high therapeutic effect and selectivity.
Key Features and Benefits
Impact
Team
Siva Kumar Rokkam,# Javier A. Mas-Rosario,# Bishnu P. Joshi, Mayank Joshi, Angshuman Roy Choudhury, Swayamsiddha Kar, Nageswara Rao Golakoti,* and Michelle E. Farkas. *
* Corresponding authors, #Equal contributions.
Title of paper: Diarylidene-N-Methyl-4-Piperidones and Spirobibenzopyrans as Antioxidant and Anti-Inflammatory Agents.
Read Paper Here: https://doi.org/10.1002/cbdv.202300822
Figure: Anti-inflammatory activity of diarylidene-N-methyl-4-piperidones and spirobibenzopyrans.
The Department of Chemistry, Sri Sathya Sai Institute of Higher Learning, organized an International Symposium on, “Recent Trends in Sustainability in Chemical Sciences” on 16th December 2023 at Prasanthi Nilayam Campus.
The symposium examined the status quo of the sustainability domain from multiple perspectives of academia, industry, and management. Eminent international and national speakers, from diverse backgrounds shared their valuable insights encompassing various facets of sustainability ranging from recycling, the packaging industry, socio-economic considerations, management principles, industry challenges and breakthroughs, fundamentals, and scope of applications in materials science.
The importance of Science and its contribution to Human development has been phenomenal over the last century.
In 1986, the Govt of India declared Feb 28 as National Science Day (NSD) to commemorate the discovery of the Raman Effect by prominent physicist Sir Chandrasekhara Venkata Raman who was awarded the Nobel Prize for the discovery in 1930. Since then, NSD has been celebrated across the country to highlight the significance and role of Science in everyday life, on February 28.
On this occasion, theme-based science communication activities are carried out all over India. Sri Sathya Sai Institute of Higher Learning (SSSIHL) has been celebrating National Science Day every year on all its campuses. This year, SSSIHL is jointly organizing and celebrating National Science Day 2024 (NSD – 2024) in collaboration with Sri Sathya Sai Higher Secondary School, Smt Eswaramma High School, Sri Sathya Sai Vidya Vahini & Nexus Consulting.
As part of these celebrations, multiple competitions such as Essay, Painting, Science Quiz, and modeling competitions will be conducted inviting school students (Class 8 to Class 12) from across India to participate. The registrations for these different competitions will start on 10th November and close by 30th November 2023.
The finals for these competitions will be held In Person from February 27th – 28th, 2024 @ Prasanthi Nilayam (PSN) Campus, SSSIHL, A.P.
View Competition Rules & Regulations
Click on the links below to Register by 30 November 2023:
For any Queries Contact:
Email: [email protected] | Mobile: +91 7901286254
Sri Sathya Sai Institute of Higher Learning (SSSIHL) has been celebrating National Science Day for the last five years. This year, SSSIHL has jointly organized and celebrated National Science Day 2023 (NSD – 2023) in collaboration with Dr. K. V. Rao Scientific Society (KVRSS), Sri Sathya Sai Seva Organizations (SSSO), India, and Nexus Consulting, Bangalore at the Prasanthi Nilayam campus.
As part of NSD 2023 celebrations, different competitions were organized for both school and college students, namely Essay, Painting, and Quiz were organized for schools across India to participate.
The registrations for these three different competitions were held between January 16 -February 7, 2023. Each of these competitions witnessed over 300 registrations from over 19 States in India.
On National Science Day, 28 February 2023, the Finalists of all the competitions convened at the Prasanthi Nilayam Campus, of SSSIHL and participated in the grand finale.
The winners were all felicitated during the Valedictory ceremony by the Honorable Chancellor, SSSIHL, Sri K Chakaravarthi, the Managing Trustee of Sri Sathya Sai Central Trust Sri R J Ratnakar and the Vice-Chancellor (Acting) Prof B. Sai Giridhar. Further, the members and guests of Dr. K. Rao Scientific Society too were felicitated by the dignitaries.
A detailed report with photographs from the Finale event is enclosed here.
View Recording:
Quiz Finals: https://www.youtube.com/live/27LW-00-Yls?si=apSdirI4y0xYXXep
https://www.youtube.com/live/35b_ZbFmT7M?si=2zx0Y68Z-k8rq9y8
https://www.youtube.com/live/FWalNznu35Q?si=JVMUn8jv9pBXT6Fi
Identifying the Issue
An effort to study the relationship between cycloalkanone ring size and the observed NLO properties of bischalcones
Objective of the Research
To explore the effect of the cycloalkanone ring size on the NLO properties of bischalcones
Who should read this?
Faculty, Research scholars, and Students of Optics and Organic Chemistry
Solution
With the objective of establishing the effect of cycloalkanone ring size on the NLO properties of bischalcones para-substituted diarylideneacetone and substituted diarylidenecycloalkanone derivatives were synthesized by the Claisen–Schmidt condensation reaction and characterized by using UV-vis, FT-IR, 1H NMR, 13C NMR and mass spectrometry. The second harmonic generation (SHG) efficiencies and third-order nonlinear optical (NLO) properties of the synthesized compounds were studied. Among all the synthesized compounds, 2,6-bis-(4-methoxybenzylidene) acetone showed the highest SHG efficiency (12.96 times that of urea) and 2, 6-bis–(4-methylthiobenzylidene) cyclopentanone showed the highest third order NLO property with χ (3) value of 2.650 ± 0.02310-13. Among the diarylidenecycloalkanones SHG efficiency decreased with an increase in the cycloalkanone ring size. Diarylidenecyclopentanone series showed the best third-order NLO activity followed by diarylideneacetone, diarylidenecycloheptanone, and diarylidenecyclohexanone series. The results indicate that the cycloalkanone ring size as well as the presence of substituent on the aryl ring affect the NLO properties.
Key Features and Benefits
The results of the study help in the design of bischalcones with potential NLO properties
Impact
Enriches the knowledge of preparing organic compounds with good NLO properties
Team
Title of paper: Effect of cycloalkanone ring size on second and third order nonlinear optical properties of Bischalcones
Read Paper Here: https://doi.org/10.1016/j.optmat.2023.113825
Identifying the Issue
Objective of the Research
Who should read this?
Research community working in the Antiplasmodial drug development, medicinal chemists, and pharmaceutical industry.
Solution
Development of nontoxic small molecules with high therapeutic effect and selectivity.
Key Features and Benefits
Impact
Team
Title of paper: Antiplasmodial and Antimalarial Activity of 3,5-Diarylidenetetrahydro-2H-pyran-4(3H)-ones via Inhibition of Plasmodium falciparum Pyridoxal Synthase
Read Paper Here: https://doi.org/10.1002/cmdc.202200411
Identifying the Issue
Malarial parasites are becoming resistant to presently used drugs, for this reason, there is a need for new and better antimalarial drugs.
Objective of the Research
To semi-synthesize isoandrographolide acetals from the natural product andrographolide and study their antimalarial potency.
Who should read this?
Faculty, research scholars, and students of Medicinal and Organic chemistry.
Solution
Isoandrographolide and its nineteen acetals were synthesized and characterized using 1H-NMR, 13C-NMR, mass spectrometry, IR, and UV spectroscopy. Out of these fifteen isoandrographolide acetals are novel. The compound (3,19)-4-Methoxy-benzylidene-isoandrographolide was characterized using single-crystal X-ray diffraction also. All the compounds were tested for their anti-plasmodial potencies (IC50) against the chloroquine-sensitive Pf3D7 and chloroquine-resistant PfINDO strains. Potent compounds were further tested for their cytotoxicity (CC50) against mammalian cells. The activity of the compounds is influenced by various factors like the type of substituent, its position, and also its bulkiness. Thus, from this study it can be concluded that acetals of isoandrographolide can be explored as potential anti-plasmodial leads.
Key Features and Benefits
Impact
Potential as leads in the development of antimalarial drugs
Team
Title of paper: Synthesis and Anti‑Plasmodial Activity f Isoandrographolide Acetals
Read Paper Here: https://doi.org/10.1007/s11696-023-02684-9
Identifying the Issue
Inhalation exposure to endocrine disruptors (Phthalic acid esters (PAEs)) and polycyclic aromatic hydrocarbons associated with serious health effects. However, the available methods for the analysis of PAEs and PAHs are time consuming methods based on gas chromatography coupled to mass spectrometry. There is a need for a robust analytical method for the simultaneous determination of PAEs and PAHs.
Objective of the Research
Who should read this?
It is applicable to all the scientific and social community researchers as this work highlights health risk associated with the inhalation exposure to PAEs and PAHs bound to ambient fine particulate matter. Anyone who works in the Atmospheric and Analytical chemistry.
Solution
Liquid chromatography coupled electrospray ionization source mass spectrometry is a robust, sensitive and high performance analytical technique for the qualitative and quantitative analysis of organic composition from a sample. However, to the best of our knowledge there are no methods for the simultaneous determination of endocrine disruptors (PAEs) and PAHs using LC-MS/MS. In the present study, we had optimized a novel LC-MS/MS method for the simultaneous determination of endocrine disruptors and PAHs bound to ambient fine particulate matter. In this method, we report the quantification of targeted compounds faster than the earlier reported gas chromatography – mass spectrometry methods with better sensitivity for benzyl butyl phthalate (0.03 ng m-3) and di-butyl phthalate (0.33 ng m-3). This method has been deployed for the analysis for the endocrine disruptors and PAHs bound to ambient fine particulate matter samples collected at IISER Mohali in North West Indo-Gangetic plain.
Key Features and Benefits
Impact
This work presents the novel method for the simultaneous analysis of endocrine disruptors and PAHs bound to ambient fine particulate matter (PM2.5). The reported results suggest that benzo (a) pyrene (B[a]P) (Group 1 Carcinogen) exceeded the threshold limits set by National Ambient Air Quality Standards, India. This study shows that exposure to PAEs and PAHs bound to PM2.5 should be of concern at the sampling site.
Team
Paper Published in: Atmospheric Environment (Elsevier)
Title of paper: Optimized LC-MS/MS method for simultaneous determination of endocrine disruptors and PAHs bound to PM2.5: Sources and health risk in Indo-Gangetic Plain
Read Paper Here: https://doi.org/10.1016/j.atmosenv.2022.119363
Augmenting Writing Skills for Articulating Research (AWSAR) an initiative by the Department of Science and Technology (DST) aims to disseminate Indian research stories among the masses in an easy-to-understand and interesting format to common-man.
The annual AWSAR award, was constituted to encourage Ph.D. Scholars and Post-Doctoral Fellows (PDFs) in Science and Technology (S&T) streams to write popular science articles by participating in a national competition.
The results of the 2021 AWSAR awards were announced at a ceremony that was streamed live on YouTube, Facebook, and India Science websites on National Science Day, 28 February 2022. A panel of eminent science communicators and scientists, constituted by DST, evaluated the entries.
From over 4000+ participants, Ms. Amitananda Dash, Research Scholar from the Department of Chemistry, Sri Sathya Sai Institute of Higher Learning, Anantapur Campus, was selected as one of the top 100 awardees for her popular science story titled “Cancer- The Nemesis”. Her story highlighted the innovative research on cancer being carried out currently in the labs at SSSIHL.
Ms. Amitananda Dash received a Certificate of Appreciation along with prize money of Rs. 10,000/- as part of the award.
For more on the award: https://www.awsar-dst.in/results-2021
