Curcumin related analogues possess antioxidant and anti-inflammatory properties and may be used as curcumin substitutes with improved Pharmacological properties

Identifying the Issue

• Inflammation is a hallmark of chronic diseases
• Curcumin’s poor bioavailability impedes its use as an effective anti-inflammatory agent

Objective of the Research

• To synthesize curcumin analogues with enhanced bioavailability and anti-inflammatory properties

Who should read this?

Research community working in anti-inflammatory drug development, medicinal chemists, and the pharmaceutical industry

Solution

Development of nontoxic small molecules with high therapeutic effect and selectivity.

Key Features and Benefits

• Development of diarylidene-N-methyl-4-piperidones (curcumin-related analogues) with promising antioxidant and anti-inflammatory properties
• Reduced the expressions of iNOS and NO.
• The synthesized analogues have better water solubility than curcumin.

Impact

• Potent compounds from this study have better water solubility, antioxidant and anti-inflammatory properties than curcumin
• Effective against chronic inflammation.
• Lead compounds from this study offer new and more effective treatment options for various types of inflammation.

Team

Siva Kumar Rokkam,^# Javier A. Mas-Rosario,^# Bishnu P. Joshi, Mayank Joshi, Angshuman Roy Choudhury, Swayamsiddha Kar, Nageswara Rao Golakoti,^* and Michelle E. Farkas. ^*

* Corresponding authors, ^#Equal contributions.

Title of paper: Diarylidene-N-Methyl-4-Piperidones and Spirobibenzopyrans as Antioxidant and Anti-Inflammatory Agents.

Read Paper Here: https://doi.org/10.1002/cbdv.202300822

Figure: Anti-inflammatory activity of diarylidene-N-methyl-4-piperidones and spirobibenzopyrans.