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Research Projects - New

Granting Agency

Principal Investigator & Title of the Project

Time Period

Total Allocation

CSIR

Prof. G Nageswara Rao

2017 to 2020
₹24 Lakhs
Synthesis of novel Andrographolide derivatives as potential anticancer and antibacterial agents

Scope: Studies have reported that andrographolide and its analogues possess a wide range of biological activities such as anticancer, antidiabetic, anti-inflammatory, etc. Hence, our objective is to synthesize new and novel andrographolide derivatives as potent anticancer and antibacterial agents with improved in vivo metabolic stability.
Deliverables
  • New andrographolide analogues with improved biological activities (anti-cancer and anti-bacterial activity)
Social Relevance: 

As many of the existing anti-cancer drugs are having side effects, there is a need for exploring and developing potent anti-cancer drugs with improved activity and minimal side effects. Many of the anti-biotics drugs are becoming less effective against drug resistant bacteria. To address this problem, we need to develop effective anti-bacterial compounds. The present work is aimed at answering these issues by developing potent anticancer and anti-bacterial agents and hence is of social relevance.

Granting Agency

Principal Investigator & Title of the Project

Time Period

Total Allocation

4S Foundation (USA)

Dr. Srikanth Sola and Prof. Chelli Janardhana

2016 to 2018
₹10 Lakhs
Development and Validation of an indigenous high sensitivity – low cost paper based assay for Lp-PLA2 and other cardiac markers to identify Indians at risk for early onset of coronary artery disease

Scope: Lipoprotein associated phospholipase A2 (Lp-PLA2) is a potent pro-inflammatory mediator which plays an important role in the development of coronary atherosclerosis. Lp-PLA2 has significant potential to become an important marker for early onset of atherosclerosis in Indians. However, its utility in this population is not known. It is also important to develop a high sensitivity, rural-affordable, point-of-care assay for cardiac markers specially for low resource settings.
Deliverables
  • To study the association between Lp-PLA2 and clinical outcomes in CAD patients and to evaluate the incremental value of Lp-PLA2 in comparison with traditional and emerging risk factors in identifying asymptomatic individuals at risk for CAD
  • To develop a low cost, high sensitivity, reliable Enzyme Linked Immuno Sorbent Assay (ELISA) based assay for Lp-PLA2 and lateral flow assay on paper for troponin

Research Projects - Ongoing

Granting Agency

Principal Investigator & Title of the Project

Time Period

Total Allocation

DST INSPIRE Faculty Award    

Dr. S Prathap Chandran

2013-2018    

₹35 Lakhs
Regiospecific Functionalisation of Anisotropic Nanoparticles and Implications Towards Generation of Plasmonic Metal Nanoclusters    

Research Projects - Completed

Granting Agency

Principal Investigator & Title of the Project

Time Period

Total Allocation

DST-SERB    

Dr. Sasidhar Siddabattuni

Sep 2013 – Sep 2016    
₹28.6 Lakhs    
Develop Interfacial Chemistry Based Structure-Property Relationship in Nanodielectric Composites for Enhanced Energy Storage Applications    
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