Biosciences

Achievements & Participation 2019/20

Dr. B E Pradeep
Invited Speaker at International Symposium on Discovery of Actionable Targets in Infectious Diseases, Yenepoya University, Mangalore, 26 Nov 2019.

Invited speaker at MedTech Innovation day, Re-inventing Drug discovery by digitization & Novel technologies, Jubilant Biosys, Bengaluru, 6 Dec 2019.

Invited speaker for the symposium, ESKAPE pathogens, Centre for Infectious Disease Research, Indian Institute of Science, 21 Dec 2019.

Dr. A S Vishwanathan
Resource person for Lifesciences, Regional STEM Teacher Training Workshop on Research Based Pedagogical Tools, in collaboration with Indian Institute of Science Education and Research (IISER), Pune, Oriental University, Indore, 26-28 Jun 2019.

Resource person for Lifesciences, Regional STEM Teacher Training Workshop on Research Based Pedagogical Tools, in collaboration with Indian Institute of Science Education and Research (IISER), Pune, Sir Padampat Singhania University, Udaipur, Rajasthan, 17-19 Feb 2020.

Dr. S Venketesh
Invited lecture on Metabolic Rewiring promotes Amyloidogenesis in Huntington’s disease: Potential Biomarkers and Therapeutic Targets, Recent Trends in Biosciences, St. Peter’s Institute of Higher Education and Research, Chennai, 7-8 Aug 2019.

Mrs. B Anusha
Participated in the SAKURA Science Exchange Program (organized by the Government of Japan), Japan Advanced Institute of Science and Technology (JAIST), Nomi, Ishikawa, Japan, 16-25 Aug 2020.

Dr. (Mrs.) Pallavi C
Attended a workshop on Recent Trends in Bioinformatics for Exploratory Analysis of Biological Data, St. Francis College for Women, Hyderabad, 16-18 Jan 2020.

Completed an Online Certification Course, Descriptive Statistics with R Software, The National Programme on Technology Enhanced Learning (NPTEL), May 2020 

Dr. Anandkumar K
Participated in a workshop by the International Association of Sai Vibrionics Practitioners, Prasanthi Nilayam, 17-22 Nov 2019, and have qualified as an Associate Vibrionics Practitioner.

Dr. K N Naresh
Attended a webinar on Herbals at Home for Health Management during Covid-19, The Maharaja Sayajirao University of Baroda, Gujarat, 9 May 2020. 

Attended a webinar on The Science behind Covid-19, Harvard University, Cambridge, MA, USA, 24 Apr 2020.

Achievements & Participation 2019/20

Sri Balaram Khamari
First Prize in Poster presentation, 5^th Annual South Zone Critical Care Conference, Visakhapatnam, Andhra Pradesh, 15-18 Aug 2019.

Sri Pachi Pulusu Chankya
Recipient of ICMR Senior Research Fellowship.

Achievements 2019/20

Projects & Dissertations
Listed below are the postgraduate and professional programme projects and dissertations for the academic year 2018/19:

SSSIHL Projects & Dissertations – 2019/20 – M.Sc. in Biosciences

National Examinations
A high percentage of SSSIHL postgraduate students qualified in national exams such as the GATE/JEST or the CSIR-UGC NET in 2019/20. The list below includes the national rank for each exam (if available):

GATE
Jasa Ranjan Podh (Life Sciences & Life Sciences XL) – 568
Vasudeva Tati (Life Sciences XL) – 787
Sunirmala Sahoo (Life Sciences (XL) & Life Sciences) – 161
Kodam Pradeep (Life Sciences) – 2307
Srihari M (Life Sciences) – 4610

CSIR UGC-NET for JRF
Jasa Ranjan Podh (Life Sciences & Life Sciences XL) – 85
Ayushman (Life Sciences) – 59
Sunirmala Sahoo (Life Sciences (XL) & Life Sciences) – 59
Kodam Pradeep (Life Sciences) – 56
Srihari M (Life Sciences) – 70

To access the Research Areas for the department, click here.

Publications 2019/20

Abdulrahman I Almansour, Natarajan Arumugam, Raju Suresh Kumar, D Kotresha, Thota Sai Manohar, S Venketesh, Design, synthesis and cholinesterase inhibitory activity of novel spiropyrrolidine tethered imidazole heterocyclic hybrids, Bioorganic & Medicinal Chemistry Letters, 30(2), 126789, (2020). DOI: https://doi.org/10.1016/j.bmcl.2019.126789

Natarajan Arumugam, Abdulrahman I Almansour, Raju Suresh Kumar, D Kotresha, R Saiswaroop, S Venketesh, Dispiropyrrolidinyl-piperidone embedded indeno[1,2-b]quinoxaline heterocyclic hybrids: Synthesis, cholinesterase inhibitory activity and their molecular docking simulation, Bioorganic & Medicinal Chemistry, 27(12), 2621-2628, (2019). DOI: https://doi.org/10.1016/j.bmc.2019.03.058

Kartik S Aiyer, Roshan Rai, B S Vijayakumar, Dye reduction-based electron-transfer activity monitoring assay for assessing microbial electron transfer activity of microbial fuel cell inocula, Journal of Environmental Sciences, 96, 171-177, (2020). DOI: https://doi.org/10.1016/j.jes.2020.04.037

Kartik S Aiyer, How does electron transfer occur in microbial fuel cells?, World Journal of Microbiology and Biotechnology, 36(2), 1-19, (2020). DOI: https://doi.org/10.1007/s11274-020-2801-z

Khamari B, Lama M, Pachi Pulusu C, Biswal A P, Lingamallu S M, Mukkirla B S, Sahoo A K, Dash H S N, Sharda R, Kumar P, Bulagonda E P, Molecular analyses of biofilm-producing clinical Acinetobacter baumannii isolates from a South Indian tertiary care hospital, Medical Principles and Practice, 1011-7571, (2020). DOI: https://doi.org/10.1159/000508461

Conference Presentations / Proceedings 2019/20

Khamari B, Adak S, Mangale V, Moradiya N K, Paci Pulusu C, Lama M, Bulagonda E P, Sequential progressive mutations associated with acquisition of Nitrofurantoin resistance: A study in clinically isolated Gram-negative bacteria, South Zone Conference on Critical Care (SZCC 2019) (15-18 Aug 2019) Vishakhapatnam, Andhra Pradesh.

Balaram Khamari, Sudeshna Adak, Vishakha Mangale, Neha Karshan Moradiya, Pachi Pulusu Chanakya, Manmath Lama and Bulagonda Eswarappa Pradeep, Sequential progressive mutations associated with acquisition of Nitrofurantoin resistance: A study in clinically isolated ram-negative bacteria, South Zone Conference on Critical Care (SZCC 2019) (15-18 Aug 2019) Vishakhapatnam, Andhra Pradesh.

Sahashransu S Mahapatra, A S Vishwanathan, Characterizing performance of an earthen separator in two-chambered microbial fuel cell, Advances in Chemical Sciences and Technologies (ACST – 2019) (23 Sep 2019) , National Institute of Technology, Warangal, Telangana.

Mukul Anand, Basavaraju R, Tecoma stans: a novel source of bioactive compounds with potential therapeutic benefits, National Conference on Functional Foods – Research, Innovations and Challenges (AIMIFOST 2019) (18 Dec 2019) Amity Institute of Food Technology, Amity University, Noida, Uttar Pradesh.

Prasanth Ghanta, Basavaraju R, Anti-inflammatory potential of Deoxyvasicine – An in-silico approach, International Conference on Advances in Pharmaceutical and Health Sciences (20 Feb 2020) NITTE (Deemed to be University), Mangalore, Karnataka.

Balaram Khamari, Pachi Pulusu Chanakya, Manmath Lama and Bulagonda Eswarappa Pradeep, Characterization of clinically isolated carbapenem resistant Escherichia coli, Criticare 2020 (28 Feb – 1 Mar 2020) Hyderabad. Abstract: https://www.ijccm.org/doi/IJCCM/pdf/10.5005/ijccm-24-S2-S1

Balaram Khamari, Dash H S N, Bulagonda E P, Characterization of clinically isolated carbapenem-resistant Escherichia coli, Criticare 2020 (28 Feb – 1 Mar 2020) Hyderabad. Abstracts: https://www.ijccm.org/doi/IJCCM/pdf/10.5005/ijccm-24-S2-S1

Saikrishna Srimadh Bhagavatham, Narsimulu Gumdal, Narasimhan K, Damodaram Potikuri, Rajesh Babu Dandamudi, Sai Mangala Divi, Ashish Pargaonkar, Rahul Ray, Sujith Kumar Pulukool, Vishnu Kannan, Ashwin Ashok Naik, Saibharath Simha Reddy Santha, Prakash Khanchandani, Venketesh Sivaramakrishnan, Adenosine Deaminase (ADA) reprograms metabolism and promotes onset and progression of Rheumatoid Arthritis (RA), American Society for Mass Spectrometry (ASMS) 2020 Reboot (1 Jun 2020) Virtual Conference.

Sai Manohar Thota, Sai Sanwid Pradhan, Bhavana N Reddy, Isha Verma, Rajesh Babu D, Vidyasagar K, Pavan Vasoya, Ashish Pargaonkar, Deepak Saligrama, Sunil H V, Krishna Murty V, Seshagiri Polani, Sanjaya Viswamitra, Dileep Kumar, Joshy E V, Venketesh Sivaramakrishnan, Metabolic rewiring Modulates amyloid-like aggregate formation in Huntington’s disease, American Society for Mass Spectrometry (ASMS) 2020 Reboot (1 Jun 2020) Virtual Conference.

Grant for Infrastructural Support to the Department of Biosciences
UGC SAP DRS III – ₹111 Lakhs (2018-2023)

Principal Investigator: Dr. B E Pradeep and Dr. S Venketesh

Thrust Areas: Health and Environment, and, Medically Active Natural Products

Augmenting Postgraduate Teaching & Research Facilities in Dept. of Biosciences
DST FIST – ₹88 Lakhs (2017-2020)

Principal Investigator: Dr. B S Vijayakumar

Augmenting Postgraduate Teaching & Research Facilities in Dept. of Biosciences by helping the students perform translational and applied research in the field of Biotechnology.

Perturbation in Metabolic pathways might drive Avascular Necrosis of Femoral Head by modulating bone biology: Mechanisms, Potential biomarkers and therapeutic targets
DST – ₹60.8 Lakhs (2018-2021)

Principal Investigator: Dr. S Venketesh

Avascular necrosis of the femur head (AVNFH) is a debilitating disease, which fall into three major categories: Alcohol induced, Steroid induced and idiopathic AVNFH. Clinically AVNFH is associated with impaired blood supply to the femoral head resulting in bone necrosis and collapse. The disease is characterized in some population by mutations in the MTHFR gene and elevated HC. We focus on the impairment in metabolic pathways leading to changes in HC, extracellular nucleotides and mechanisms that trigger the manifestation of AVNFH. Our data suggest an association of homocysteine pathway with AVNFH. Our model could explain all the observed symptoms and help to identify some of the events associated with AVNFH. Targeted metabolomic analysis shows elevated levels of metabolites belonging to methionine-HC, Polyamine and urea pathway as well as low levels of B12, B6 and Betain in AVNFH patients, which correlate with biophysical and histopathology of bone (Scientific Reports 2017). Further clinical and mechanistic studies are being carried out. The project will help to understand the biology of AVNFH, potential biomarkers and therapeutic targets to manage the disease.

Deliverables: The deliverables include the correlation of metabolic deregualtion with gene expression and biophysical changes in the AVNFH bone. To show the role of metabolites and cytokines like RANKL on osteoblast and osteoclast differentiation and function. To find potential biomarkers associated with disease progression and prognosis. To identify potential therapeutic targets.

Social Relevance: AVNFH is a debilitating disease which affect the productive age group between 30-50. The disease is progressive and eventually lead to total hip replacement. Hence biomarkers for early detection, progression and prognosis as well as newer therapeutic targets are imperative for managing the disease. The present project might help to achieve some of the objectives by providing a better understanding of AVNFH disease biology.

Mechanism of resistance involved in the emergence of nitrofurantoin resistance among uropathogenic enterobacteriaceae
Indian Council of Medical Research (ICMR) – ₹60 Lakhs (2020-2021)

Principal Investigator: Dr. B E Pradeep

Globally, urinary tract infections (UTI) are the most commonly encountered community and nosocomial infections and are a major cause of morbidity, significantly impacting health care related expenditure across all age groups. Enterobacteriaceae, which are gram negative, facultative anaerobic and non-spore forming bacteria, are most frequently associated with UTIs. Nitrofurantoin is recommended as the first line drug of choice for empirical treatment of uncomplicated UTIs involving Enterobacteriaceae. Of late, nitrofurantoin resistance (NR) is being reported among drug resistant Enterobacteriaceae. Very little information is available about the mechanisms employed by the pathogens in developing NR. Therefore, the proposed studies intend to fill a critical void in our understanding of the mechanisms involved in the development of resistance against one of the well tolerated antibiotics for the treatment of uncomplicated UTIs.

First, a total of 100 uropathogenic Enterobacteriaceae will be screened for the presence/absence of genes associated with NR. Second, mutations in the genes will be correlated with the resistance phenotype. Next, whole genome sequencing will be performed on select isolates to identify any novel genes/mechanisms that may have been employed to counter the antibacterial effects of nitrofurantoin. Knockout mutants will be generated and complementation assays will be performed to understand the role of the target genes in the emergence of NR. Growth curve analysis will be done to look at the fitness costs involved in the development of NR. RT-qPCR and nitro reductase activity assays will be performed to understand the genotype-phenotype relation and to delineate the signaling mechanisms underlying the emergence of NR.

The proposed study would help in understanding the mechanisms involved in Nitrofurantoin and hence may be useful in developing ways to combat the rise of Antimicrobial resistance.

Sri Prasanth Ghanta
Plant Biotechnology and Phytochemistry
Supervisor: Prof. R Basavaraju

Sri Sai Krishna S B
Rheumatoid Arthritis, Biomarker Discovery, Systems Biology, Metabolomics, Mechanistic Studies
Supervisors: Dr. S Venketesh and Dr. Prakash Kanchandani

Sri Mukul Anand
Plant biotechnology
Supervisor: Prof. R Basavaraju

Sri Thota Sai Manohar
Neurobiology
Supervisor: Dr. S Venketesh

Sri Abhinav Prakash Nair
Systems Biology of Diseases (Cardio-biology)
Supervisor: Dr. S Venketesh

Sri Kottapalli K Jayant
Fungal Biotechnology
Supervisor: Dr. B S Vijayakumar

Sri Skanda S
Fungal Biotechnology
Supervisor: Dr. B S Vijayakumar

Sri Ashwin Ashok Naik
Disease Biology
Supervisor: Dr. S Venketesh

Sri Balaram Khamari
Molecular Microbiology, Antimicrobial Resistance
Supervisor: Dr. B E Pradeep

Sri Manmath Lama
Molecular Microbiology, Bacterial Genomics
Supervisor: Dr. B E Pradeep

Sri Pachi Pulusu Chankya
Molecular Microbiology, Antimicrobial resistance, Genomics
Supervisor: Dr. B E Pradeep

Sri Roshan Rai
Molecular Microbiology
Supervisor: Dr. B S Vijayakumar

Sri Sai Sanwid Pradhan
Systems Biology of Diseases
Supervisor: Dr. S Venketesh

Sri Saiswaroop R
Neurobiology
Supervisor: Dr. S Venketesh

Sri R Sriram
Systems Biology of Diseases
Supervisor: Dr. R Sai Sathish and Dr. S Venketesh

Sri Utkarsh Bele
Microbial Biotechnology and Wastewater Treatment
Supervisor: Dr. B S Vijayakumar

Sri V M Datta Darshan
Protein Biology
Supervisor: Dr. S Venketesh

Sri Sahashransu Satyajeet Mahapatra
Wastewater treatment and reuse
Supervisor: Dr. A S Vishwanathan

Sri Arun Sai Kumar Peketi
Understanding the mechanisms of Colistin resistancee in Bacteria
Supervisor: Dr. B E Pradeep

Sri Sudam Bhoi
Protein Structure and Function
Supervisor: Dr. K N Naresh

Sri Mukkirla Bhargava Sai
Molecular Biology
Supervisor: Dr. Anandkumar K

Sri Piyush Kumar
Bioactive compounds of endophytic fungi associated with medicinal plant
Supervisor: Dr. V N S Malleswara D Kota